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Perinatal Iron and Copper Deficiencies Alter Neonatal Rat

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Transcriptome-wide identification of novel circular RNAs

Hsieh LC,Lin SI,Shih ACC,Chen JW,Lin WY,Tseng CY,et al.Uncovering small RNA-mediated responses to phosphate deficiency in Arabidopsis by deep sequencing.Plant Physiology.2009;151(4):212032.doi 10.1104/pp.109.147280 19854858Transcriptional regulation of copper metabolism genes in Oct 28,2014 Perinatal Iron and Copper Deficiencies Alter Neonatal Rat#0183;None of the genes were significantly affected by iron deficiency,suggesting that changes in expression cannot explain the altered copper levels in the fetal and neonatal liver.Keywords Copper-iron interactions Perinatal development Metallochaperones ATP7ATitle Assistant Professor at UniversityLocation Greater Minneapolis-St.PaulConnections 87Pediatrics - Neonatology Research Output Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone concentrations Bastian,T.W.,Prohaska,J.R.,Georgieff,M.K. Anderson,G.W.,Aug 2010 ,In Endocrinology.151 ,8 ,p.4055-4065 11 p.

Thyroid Support Complex - ThyroMate

Those who are deficient in copper may experience hypothyroid symptoms.Sufficient copper also ensures adequate utilization of iron in the body.1.Bastian TW,Prohaska JR,Georgieff MK,Anderson GW.Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone concentrations.Endocrinology.2010 Aug;151(8):4055-65.2.Thomas Bastian - Assistant Professor - University of Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone concentrations.Endocrinology 2010Thomas BASTIAN Assistant Professor PhD University of Copper,iron and iodine/thyroid hormone (TH) deficiencies disrupt brain development.Neonatal Cu deficiency causes Fe deficiency and may impact thyroidal status.

Suppressed hepcidin expression correlates with

Mar 29,2012 Perinatal Iron and Copper Deficiencies Alter Neonatal Rat#0183;These CuD rats had lower hemoglobin and plasma iron levels than copper-adequate (CuA) controls.The lower holotransferrin (plasma iron) and lower expression of transferrin receptor 2 (TfR2),a sensor of plasma iron,correlated well with lower Hamp expression.BMP6 levels were not impacted by CuD in that study (Jenkitkasemwong et al.2010).Relationship:444 - AOP-WikiHow Does This Key Event Relationship Work.It is widely accepted that the thyroid hormones (TH) have a prominent role in the development and function of the Central Nervous System (CNS) and their action has been closely linked to the cognitive function because of their importance in the neocortical development (Gilbert et al.,2012).Rat brain iron concentration is lower following perinatal Concentration of brain copper and iron,based on fresh weight,in suckling rats during perinatal Cu deficiency.Each point is the mean Perinatal Iron and Copper Deficiencies Alter Neonatal Rat#177; SEM of four male rats from separate litters.Cu-deficient (open circles) values for both copper and iron were lower than values for Cu-adequate (solid circles) pups except for brain iron at P3,p Perinatal Iron and Copper Deficiencies Alter Neonatal Ratlt; 0.05.

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Copper (Cu),iron (Fe),and iodine/thyroid hormone (TH) deficiencies lead to similar defects in late brain development,suggesting that these micronutrient deficiencies share a common mechanism contributing to the observed derangements.Previous studies in rodents (postweanling and adult) and humans (adolescent and adult) indicate that Cu and Fe deficiencies affect thePerinatal Iron and Copper Deficiencies Alter Neonatal Rat Perinatal Iron and Copper Deficiencies Alter Neonatal Rat Circulating and Brain Thyroid Hormone Concentrations .By Thomas W.Bastian,Joseph R.Prohaska,Michael K.Georgieff and Grant W.Anderson.Abstract.Copper (Cu),iron (Fe),and iodine/thyroid hormone (TH) deficiencies lead to similar defects in late brain development,suggesting that

Perinatal Iron and Copper Deficiencies Alter Neonatal Rat

Perinatal Fe and Cu deficiencies reduced serum total T 4 and T 3 concentrations in nursing neonatal rats (Fig.2 2,,A and B).This result is consistent with previous studies in postweanling young adult CuD or FeD rats also demonstrating reductions in circulating T 4 and T 3 concentrations (Perinatal Iron Deficiency Predisposes the Developing Rat As iron and iron-containing enzymes are essential for normal neurodevelopment,perinatal iron deficiency may predispose the developing hippocampus to greater HI injury.In developing rats,perinatal iron deficiency adversely affects oxidative phosphorylation in the hippocampus,as indexed by decreased cytochrome c oxidase activity selectively in this brain region ( deUngria et al ,2000 ).Perinatal Anemia - Pediatrics - MSD Manual Professional Nutritional deficiencies of iron,copper,folate (folic acid),vitamin E,and vitamin B12 may cause anemia in the early months of life but not usually at birth.The incidence of iron deficiency,the most common nutritional deficiency,is higher in less developed countries where it results from dietary insufficiency and exclusive and prolonged

Neurotree - Thomas W.Bastian

Neurotoxicology and Teratology.Bastian TW,Santarriaga S,Nguyen TA,et al.( 2015) Fetal and neonatal iron deficiency but not copper deficiency increases vascular complexity in the developing rat brain.Nutritional Neuroscience.Bastian TW,Prohaska JR,Georgieff MK,et al.( 2014) Fetal and neonatal iron deficiency exacerbates mild thyroid hormone insufficiency effects on male thyroidModest and Severe Maternal Iron Deficiency in Pregnancy Apr 25,2017 Perinatal Iron and Copper Deficiencies Alter Neonatal Rat#0183;Unger,E.L.et al.Behavior and monoamine deficits in prenatal and perinatal iron deficiency are not corrected by early postnatal moderate-iron or high-iron diets in rats.J.Nutr.142 ,Maternal iron supplementation attenuates the impact of Perinatal Cu deficiency in rats results in Fe deficient pups that exhibit anemia,low serum and tissue Fe levels .The neurochemical phenotype of TH,Cu,or Fe deficiency has many similarities including hypomyelination and altered energy metabolism.

Long-Term Circulatory Consequences of Perinatal Iron

Perinatal iron deficiency (PID) has been reported to induce developmental abnormalities,including cardiovascular complications in rats.These complications are believed to be programmed by an aberrant perinatal environment because the changes persist long after the insult is corrected (ie,despite subsequent iron replenishment).Long-Term Circulatory Consequences of Perinatal Iron Perinatal iron deficiency (PID) has been reported to induce developmental abnormalities,including cardiovascular complications in rats.These complications are believed to be programmed by an aberIron,copper and fetal development Proceedings of the Prohaska,JR Bailey,WR (1994) Regional specificity in alterations of rat brain copper and catecholamines following perinatal copper deficiency.Journal of Neurochemistry 63 ,1551 1557 Prohaska ,JR Brokate ,B ( 2002 ) The timing of perinatal copper deficiency in mice influences offspring survival .

Iron assessment to protect the developing brain The

Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone concentrations.Iron Deficiency Alters Auditory Recognition Memory in Jun 01,2004 Perinatal Iron and Copper Deficiencies Alter Neonatal Rat#0183;deUngria M,Rao R,Wobken JD,Luciana M,Georgieff MK 2000 Perinatal iron deficiency decreases cytochrome c oxidase (CytOx) activity in selective regions of neonatal rat brain.Pediatr Res 48 Iron Concentration Does Not Differ in Blood but Tends to Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone concentrations.Endocrinology 151 40554065.10.1210/en.2010-2252 - DOI - PMC - PubMed Show all 86 references LinkOut - more resources Full Text Sources.Europe PubMed Central

Identification of QTLs for resistance to maize rough dwarf

1.Ali F,Yan J.Disease resistance in maize and the role of molecular breeding in defending against global threat.Journal of Integrative Plant Biology.2012; 54(3) 134151.doi 10.1111/j.1744-7909.2012.01105.x 22333113Grant Anderson,PhD School of Nursing - University of Section sub-menuGrant Anderson,PhD Masonic Cancer Center - University Fetal and neonatal iron deficiency reduces thyroid hormone-responsive gene mRNA levels in the neonatal rat hippocampus and cerebral cortex.(2012) Endocrinology.153(11) 5668-80.Bastian TW,Prohaska JR,Georgieff MK,Anderson GW.Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone concentrations.

Grant Anderson,PhD College of Pharmacy - University of

Fetal and neonatal iron deficiency reduces thyroid hormone-responsive gene mRNA levels in the neonatal rat hippocampus and cerebral cortex.(2012) Endocrinology.153(11) 5668-80.Bastian TW,Prohaska JR,Georgieff MK,Anderson GW.Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone concentrations.Gestational-neonatal iron deficiency suppresses and iron Others and we have shown that Akt-regulated mTOR signaling,a primary downstream IGF-signaling effector,is altered by iron deficiency in neonatal or juvenile rats (12,43).Based on the concurrence of iron deficiency and disrupted IGF signaling in clinical populations coupled with evidence of altered Akt signaling in rodent models of iron deficiency,we hypothesized that perinatal iron deficiency lowersFrontiers Perinatal iron deficiency and neurocognitive Sep 23,2013 Perinatal Iron and Copper Deficiencies Alter Neonatal Rat#0183;Maternal Iron Deficiency and Iron Deficiency Anemia Effects on Neonatal Iron Status.As iron is concerned,the developing fetus was once considered a perfect parasite, able to acquire sufficient iron from the mother even when she was iron deficient (Young et al.,2012).This notion has fallen by the wayside,however,and it is now clear that neonatal iron stores can be compromised

Frontiers Perinatal iron deficiency and neurocognitive

Sep 23,2013 Perinatal Iron and Copper Deficiencies Alter Neonatal Rat#0183;Maternal Iron Deficiency and Iron Deficiency Anemia Effects on Neonatal Iron Status.As iron is concerned,the developing fetus was once considered a perfect parasite, able to acquire sufficient iron from the mother even when she was iron deficient (Young et al.,2012).This notion has fallen by the wayside,however,and it is now clear that neonatal iron stores can be compromisedFrontiers Iron Metabolism and Brain Development in Apr 25,2019 Perinatal Iron and Copper Deficiencies Alter Neonatal Rat#0183;Iron deficiency alters iron regulatory protein and iron transport protein expression in the perinatal rat brain.Pediatr.Res.53,800807.doi 10.1203/01.PDR.0000058922.67035.D5Formula - ThyroMate1.Bastian TW,Prohaska JR,Georgieff MK,Anderson GW.Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone concentrations.Endocrinology.2010 Aug;151(8):4055-65.2.Lukaski H C et al.Body temperature and thyroid hormone metabolism of copper deficient rats.Nutr Biochem 1995;6:445-451.

Fetal iron deficiency alters the proteome of adult rat

Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone concentrations.Endocrinology 151 40554065,2010.Crossref PubMed ISI Google Scholar; 3.Beard J,Erikson KM,Jones BC.Neonatal iron deficiency results in irreversible changes in dopamine function in rats.J Nutr 133 11741179,2003.Event:1116 - AOP-WikiPerinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone concentrations.Endocrinology,151(8),pp.4055-4065.Bastian,T.W.,Anderson,J.A.,Fretham,S.J.,Prohaska,J.R.,Georgieff,M.K.and Anderson,G.W.,2012.Dr.Michael K.Georgieff,Neonatologist in Minneapolis,MN Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone concentrations.Bastian,T.W.,Prohaska,J.R.,Georgieff,M.K.,Anderson,G.W.

Copper Deficiency And Excess In Infancy Developing A

This is relevant because formula and other infant foods are often supplemented with zinc and iron,which may to some degree impair copper absorption.In the case of zinc,decreased copper absorption has been observed only at high zinc doses.Tissue copper retention in rats was lower on a soy protein diet compared to a lactalbumin-based diet .It is not clear from these studies whether effects of soyCited by 79Publish Year 2010Author Thomas W.Bastian,Joseph R.Prohaska,Michael K.Georgieff,Grant W.AndersonPerinatal iron and copper deficiencies alter neonatal rat title = Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone concentrations,abstract = Copper (Cu),iron (Fe),and iodine/thyroid hormone(TH) deficiencies lead to similar defects in late brain development,suggesting that these micronutrient deficiencies share a common mechanism contributing to the observed derangements.Cited by 79Publish Year 2010Author Thomas W.Bastian,Joseph R.Prohaska,Michael K.Georgieff,Grant W.AndersonPerinatal iron and copper deficiencies alter neonatal rat Jun 23,2010 Perinatal Iron and Copper Deficiencies Alter Neonatal Rat#0183;Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone concentrations.Thomas W Bastian Department of Pharmacy Practice and Pharmaceutical Sciences,College of Pharmacy,University of Minnesota Duluth,Duluth,Minnesota 55812,USA.

Cited by 79Publish Year 2010Author Thomas W.Bastian,Joseph R.Prohaska,Michael K.Georgieff,Grant W.AndersonPerinatal iron and copper deficiencies alter neonatal rat

Cu deficiency reduced serum total T (3) by 48%,serum total T (4) by 21%,and whole-brain T (3) by 10% at P12.Fe deficiency reduced serum total T (3) by 43%,serum total T (4) by 67%,and whole-brain T (3) by 25% at P12.Brain mRNA analysis revealed that expression of several TH-responsive genes were altered in CuD or FeD neonates,suggesting that reduced TH concentrations were sensed by the FeD and CuD neonatalCited by 79Publish Year 2010Author Thomas W.Bastian,Joseph R.Prohaska,Michael K.Georgieff,Grant W.AndersonPerinatal Iron and Copper Deficiencies Alter Neonatal Rat Perinatal Iron and Copper Deficiencies Alter Neonatal Rat Circulating and Brain Thyroid Hormone Concentrations Thomas W.Bastian,Joseph R.Prohaska,Michael K.Georgieff,and Grant W.Anderson Department of Pharmacy Practice and Pharmaceutical Sciences (T.W.B.,G.W.A.),College of Pharmacy,Cited by 79Publish Year 2010Author Thomas W.Bastian,Joseph R.Prohaska,Michael K.Georgieff,Grant W.AndersonPerinatal Iron and Copper Deficiencies Alter Neonatal Rat Aug 01,2010 Perinatal Iron and Copper Deficiencies Alter Neonatal Rat#0183;Perinatal Fe and Cu deficiencies reduced serum total T 4 and T 3 concentrations in nursing neonatal rats (Fig.2,A and B).This result is consistent with previous studies in postweanling young adult CuD or FeD rats also demonstrating reductions in circulating T 4 and T 3 concentrations ( 17 ,18 ,19 ,20 ,21 ,22 ).

Brain Iron Metabolism Dysfunction in Parkinsons Disease

Bastian TW,Prohaska JR,Georgieff MK,Anderson GW (2010) Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone concentrations.Endocrinology 151(8):40554065.doi 10.1210/en.2010-0252Association of antiepileptic drug usage,trace elements Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone concentrations. Fetal and neonatal iron deficiency reduces thyroid hormone-responsive gene mRNA levels in the neonatal rat hippocampus and cerebral cortex.3 Health Effects of Copper Deficiencies Copper in THE essentiality of copper for animals was reported in 1928 in a study showing that it is essential for erythropoiesis in rats fed a milk-based diet (Hart et al.1928).Erythropoiesis was improved when copper sulfide containing ash was added back to the diet (Hart et al.1928).Reports of copper-deficiency in grazing livestock followed,further substantiating the essentiality of copper (Neal

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Nov 01,2011 Perinatal Iron and Copper Deficiencies Alter Neonatal Rat#0183;Copper,iron and iodine/thyroid hormone (TH) deficiencies disrupt brain development.Neonatal Cu deficiency causes Fe deficiency and may impact thyroi(PDF) The Timing of Perinatal Copper Deficiency in Mice 3142 GESTATIONAL TIMING AND COPPER-DEFICIENT MICE 3143 TABLE 1 Timing of perinatal copper deficiency alters mouse pup survival1 Experiment 1 Experiment 2 Characteristic Copper-adequate Copper-deficient Copper-adequate Copper-deficient Diet onset E13 E13 E19 E19 Pregnant dams 3/4 3/5 4/6 5/7 Litter size,2 n 9 1.0 10 1.5 7.5 1.9 7.4 (PDF) Inhibiting the interaction between apoptosis Perinatal brain injury is an important cause of developmental a nd AIF deficiency leads to mitochondria dy sfunction and in the neonatal rat after cerebral hypoxia-ischemia.

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